RESUMO
Introduction: New cone-beam computed tomography (CBCT) devices are capable of imaging with different resolutions and field of views (FOVs), in which higher resolutions and FOVs impose a higher dose to the patient. This study was an attempt to investigate the detection accuracy from different FOVs and resolutions in detection of horizontal root fractures. Methods and Materials: Through this experimental study, in five different field of views (FOV) and resolutions (voxel size) of New Tom VGi CBCT (Italy) system was used to scan fifty teeth with horizontal root fractures in half of them. The images were evaluated by four observers (two maxillofacial radiologists and two general dentists) who recorded the presence or absence of horizontal root fractures. The data were analyzed by SPSS 22 software and MacNemar and kappa test were used to compare results with reality. Results: The highest sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy (AZ) were attributed to 8×8 FOV and high resolutions (0.125 mm voxel size) but the difference between sensitivity, specificity, PPV and NPV was not significant. Kappa values for inter-observer agreement between radiologists and general dentists and also intra-observer agreement were in excellent ranges. The highest Kappa in both cases was attributed to 8×8 FOV and high resolutions. Conclusion: There was no significant difference to diagnose of horizontal root fracture between two observer groups and for all of the FOVs and voxel sizes.
RESUMO
BACKGROUND: Patients with early stage breast cancer with same treatment strategy can have markedly different outcomes. Human epidermal growth factor receptor 2 (HER2/nue) gene amplification or the subsequent overexpression of protein has been proved to be associated with patient's outcome and response to anthracyclins-based regimens. OBJECTIVES: This study assessed prognostic value of HER2/nue marker in patients with early stage breast cancer who received adjuvant chemotherapy with anthracyclins-based regimens. MATERIALS AND METHODS: Fifty tissue samples from patients with primary breast cancer of moderate risk receiving sequential adjuvant chemotherapy with anthracyclins-based regimens were assessed to evaluate HER2/nue gene status (quantified by Immunohistochemistry and fluorescence in situ hybridization) retrospectively. Besides, correlation of HER2/neu with patients' characteristics and outcome was studied. RESULTS: HER2/neu amplification was identified in 19 (38%) of 50 patients. No significant difference regarding HER2/neu status was seen in clinic pathological characteristics of patients. Although Progression Free Survival (PFS) was shorter in HER2 overexpressed group, but uni/multivariate analysis adjusted for HER2 overexpression, nodal involvement, hormone receptor status, age and tumor size revealed no significant predictive and/or prognostic value for HER2 regarding PFS. CONCLUSIONS: This study on a limited number of patients treated with adjutant anthracyclins-based regimens, revealed that HER2/neu is not a unique strong predictor for outcome, thus according to combination of HER2/neu status and other clinical factors, it is necessary to distinguish patients at high risk of recurrence.
RESUMO
BACKGROUND: Odontogenic cysts are relatively common lesions which can cause different complications. As demographic information is lacking in Iran and specially in Isfahan, the aim of this study was to determine the prevalence of odontogenic cysts according to age, gender and affected area among patients referring to the Oral Pathology Department of the Dental School of Isfahan University of Medical Sciences (Iran) over a 23-year period. MATERIALS AND METHODS: A total of 7412 diagnosed lesions recorded in the Oral Pathology Department archives of Isfahan Dental School between 1988 and 2010 were reevaluated, then odontogenic cysts were separated through reviewing microscopic slides according to the 2005 World Health Organization classification and variables such as age, gender, the infected jaw, and its specific region were obtained by SPSS Version 16.0 from the recorded database. RESULTS: 21.62% of the lesions were odontogenic cysts, of which 48.72% were inflammatory and 51.28% were developmental cysts. These cysts were more common in the mandible. The mean age of patients was 29.53 ± 16.1. Male to female ratio was 1.31:1. The four most frequent odontogenic cysts were radicular cysts (35.12%), dentigerous cysts (25.77%), odontogenic keratocysts (22.58%) and residual cysts (12.98%). CONCLUSION: Odontogenic cysts are fairly frequent jaw lesions (21.62%), of which radicular cyst was the most common cyst. The four most common lesions constituted a sum of 96.45% of the total. In general, the prevalence rates in our study are similar to the studies from other geographic parts of the world but with a lower incidence of inflammatory cysts, higher prevalence of dentigerous cysts and residual cysts and also mandibular predominance for residual cysts.
RESUMO
BACKGROUND: The aim of this study was to record the relative frequency of odontogenic tumors (OTs), evaluate and analyze the epidemiological features of the lesions in patients referring to dental faculty of Isfahan and compare these data with previous studies. MATERIALS AND METHODS: In this study, we reviewed the records of 6,860 lesions from 1988 to 2010 archived in the oral pathology department of dental faculty of Isfahan retrospectively and using criteria for histological typification published by the WHO in 2005. Age, sex, site and extent of tumors were analyzed. RESULTS: Among recorded lesions 260 were OTs (3.79%). Of these, 259 were benign and just 1 was malignant. The most common lesions were ameloblastomas (n = 95) followed by odontomas (n = 86), odontogenic myxomas (n = 24) and others. There were a few more female patients (n = 133, 51.15%) than male and the mean age of patients was 27.8 years (range 1.5-80 years). The posterior of mandible was the most common site (n = 86, 33%). CONCLUSION: According to accumulated data, odontogenic tumors are uncommon lesions and malignant tumors are very rare.
